chebulagic acid
| Name | Chebulagic acid | ||
| PubChem CID | 250397 | ||
| Molecular Weight | 954.7g/mol | ||
| Synonyms |
chebulagic acid |
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| Formula | C₄₁H₃₀O₂₇ | ||
| SMILES | C1C2C3C(C(C(O2)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C6=C5C(C(C(=O)O3)CC(=O)O)C(C(=O)O6)O)O)O)OC(=O)C7=CC(=C(C(=C7C8=C(C(=C(C=C8C(=O)O1)O)O)O)O)O)O | ||
| InChI | 1S/C41H30O27/c42-13-1-8(2-14(43)24(13)49)35(56)68-41-34-33-31(64-39(60)12(6-19(47)48)22-23-11(38(59)67-34)5-17(46)27(52)32(23)65-40(61)30(22)55)18(63-41)7-62-36(57)9-3-15(44)25(50)28(53)20(9)21-10(37(58)66-33)4-16(45)26(51)29(21)54/h1-5,12,18,22,30-31,33-34,41-46,49-55H,6-7H2,(H,47,48) | ||
| InChIKey | HGJXAVROWQLCTP-UHFFFAOYSA-N | ||
| CAS Number | 23094-71-5 | ||
| ChEMBL ID | CHEMBL1970427 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | DingXiang | ||
| Use Part | Flower Bud | ||
| Habitat | Malaysia , Indonesia | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Lung, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Myrtales
-->Family: Myrtaceae
-->Genus: Syzygium
-->Species: Syzygium aromaticum
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| Chineses Pinyin | HeZiYe | ||
| Use Part | Leaf | ||
| Habitat | YunNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, GuangDong, GuangXi | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Myrtales
-->Family: Combretaceae
-->Genus: Terminalia
-->Species: Terminalia chebula
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| Chineses Pinyin | JuJiangYe | ||
| Use Part | Leaf | ||
| Habitat | GuangDong, GuangXi | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung, Spleen, Liver | ||
| Chineses Pinyin | HeZi | ||
| Use Part | Fruit | ||
| Habitat | YunNan, GuangDong, GuangXi | ||
| Flavor | Bitter; Sour; Astringent | ||
| Meridian Tropism | Lung; Large Intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Myrtales
-->Family: Combretaceae
-->Genus: Terminalia
-->Species: Terminalia chebula
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| Pair Name | Chebulagic acid, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Gene Regulation | Down-regulation | Expression | PTGS2 | hsa5743 |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Activity | MAPK1 | hsa5594 | |
| Down-regulation | Activity | MAPK8 | hsa5599 | |
| Down-regulation | Activity | MAPK14 | hsa1432 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | The present study shows the efficacy of CA to overcome MDR-1 mediated drug resistance in HepG2 cells through COX-2 dependant modulation of MDR-1. | |||
